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pathway-analyst

Convert drug and phytochemical target evidence into OM-specific signaling pathway maps and vulnerability assessments.

4|1|Updated Jan 8, 2024
Search Tags:#bioinformatics#pathway analysis#multi-target#drug repurposing#network pharmacology#NF-kB#Oral mucositis
One-click install
npx skills add https://github.com/OpenSourcePharmaFoundation/ospf-ayurveda-kg --skill pathway-analyst
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: pathway-analyst
Source: https://github.com/OpenSourcePharmaFoundation/ospf-ayurveda-kg/tree/main/.claude/skills/pathway-analyst
Command: npx skills add https://github.com/OpenSourcePharmaFoundation/ospf-ayurveda-kg --skill pathway-analyst

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

It helps translate drug and phytochemical target lists into pathway-level hypotheses for Oral Mucositis (OM), identifying which signaling cascades are covered, where network vulnerabilities exist, and what combination strategies are most coherent by pathway logic.

Core Features & Use Cases

  • Pathway mapping for a target: Infer upstream regulators, downstream effectors, crosstalk, and feedback loops for OM-relevant signaling nodes (e.g., NF-κB, MAPKs, PI3K/AKT/mTOR, ceramide, Wnt/β-catenin, TLR innate immunity).
  • Pathway coverage assessment for candidate sets: Evaluate how well drug candidates and phytochemicals modulate OM-critical pathways, highlight gaps/overlap, and assess phase alignment risks (inflammation vs healing).
  • Multi-target strategy and vulnerability analysis: Recommend intervention points (hubs/bottlenecks/feedback entry points) and propose 2–3 candidate combinations that maximize pathway coverage while avoiding counterproductive directionality or timing.

Quick Start

Ask the agent to analyze pathway coverage for a provided list of OM-associated targets and candidate compounds using the processed CSV pathway-related datasets, then produce a prioritized pathway coverage report with gap analysis and a phase-aware combination recommendation.

Frequently Asked Questions about pathway-analyst

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I map drug target lists to signaling pathways for oral mucositis?▼

Pathway coverage assessment evaluates how well candidate compounds modulate OM-critical signaling nodes like NF-κB and MAPKs, highlighting network gaps, overlaps, and phase alignment risks between early inflammation and later healing stages.

What is multi-target combination strategy design in network pharmacology?▼

Multi-target combination strategy design recommends intervention points such as hubs and feedback entry points, proposing 2-3 candidate combinations that maximize pathway coverage while avoiding counterproductive directionality or timing conflicts.

Can I assess pathway vulnerabilities for drug repurposing candidates using CSV inputs?▼

Phase-aware pathway analysis aligns interventions with OM progression, evaluating candidate targets against early inflammation and later ulceration/healing phases to ensure timing-aware combination logic and avoid counterproductive directionality.

How do I evaluate phytochemical target evidence for OM-specific pathway coverage?▼

You evaluate phytochemical target evidence by converting provided target lists into OM-specific signaling pathway maps, assessing coverage and gaps across cascades like PI3K/AKT/mTOR, ceramide, and Wnt/β-catenin to prioritize candidates.

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