primekg

Search the Precision Medicine Knowledge Graph for genes, drugs, diseases, and phenotypes.

Updated Jul 1, 2026
One-click install
npx skills add https://github.com/jasrajtulsi/GRAD-SCOPE --skill primekg-jasrajtulsi
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: primekg
Source: https://github.com/jasrajtulsi/GRAD-SCOPE/tree/main/.claude/skills/primekg
Command: npx skills add https://github.com/jasrajtulsi/GRAD-SCOPE --skill primekg-jasrajtulsi

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill requires pandas, and includes scripts (resource) components.

What problem does it solve?

Finds precision-medicine relationships in PrimeKG without manually exploring a large biomedical graph, helping users move from a disease, gene, or drug name to actionable evidence quickly.

Core Features & Use Cases

  • Entity search: Locate genes, drugs, diseases, and phenotypes by name.
  • Neighbor analysis: Retrieve direct associations and relationship types for a specific node.
  • Disease context: Summarize a disease's associated genes, drugs, phenotypes, and related diseases.
  • Use case: A researcher can query Alzheimer's disease and quickly review the surrounding biological and clinical network for hypothesis generation and follow-up analysis.

Quick Start

Ask the skill to search PrimeKG for a disease or drug name and return its direct neighbors and disease context.

Frequently Asked Questions about primekg

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I search a biomedical knowledge graph for disease-associated genes and drugs?

You can search a biomedical knowledge graph by querying the Precision Medicine Knowledge Graph (PrimeKG) to retrieve genes, drugs, diseases, and phenotypes for a given query. It uses pandas-backed loading to search CSV-based graph data and return direct neighbors.

What is disease context exploration in precision medicine research?

Disease context exploration in precision medicine research summarizes a specific disease's associated genes, drugs, phenotypes, and related diseases. It retrieves direct associations from the knowledge graph to support multiscale biology tasks and hypothesis generation.

Can I find drug repurposing paths using a pandas knowledge graph workflow?

Yes, you can find drug repurposing paths using a pandas knowledge graph workflow by discovering drug-disease paths within PrimeKG. The process performs direct neighbor retrieval and optional relation filtering on CSV-based graph data for deterministic analysis.

What's the best way to retrieve direct neighbors of a gene in a biomedical graph?

The best way to retrieve direct neighbors of a gene in a biomedical graph is querying PrimeKG by entity name. It loads the graph data with pandas, performs entity searches, and returns direct associations with their specific relationship types.

Do I need pandas to query PrimeKG for biomedical entities?

Yes, you need pandas to query PrimeKG for biomedical entities. The skill requires pandas as a dependency for CSV-based graph querying, loading the data to perform entity searches, neighbor lookups, and optional relation filtering.

Why use relation filtering when analyzing a disease's biological network?

You use relation filtering when analyzing a disease's biological network to ensure deterministic analysis of specific associations. It restricts the direct neighbors retrieved from the knowledge graph, narrowing the precision medicine relationships to relevant biological and clinical evidence.