propose-designs

Analyze protein design round results and propose next-round configurations.

Updated Feb 27, 2026
One-click install
npx skills add https://github.com/alex-hh/in-silico-pgdh --skill propose-designs
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: propose-designs
Source: https://github.com/alex-hh/in-silico-pgdh/tree/main/.claude/skills/propose-designs
Command: npx skills add https://github.com/alex-hh/in-silico-pgdh --skill propose-designs

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes references (resource) components.

What problem does it solve?

This Skill helps you analyze the results of previous protein design rounds and make data-driven decisions for planning the next iteration, optimizing strategies, and improving design outcomes.

Core Features & Use Cases

  • Analyze Design Metrics: Evaluate performance across different strategies and tools (BoltzGen vs. RFdiffusion3).
  • Propose Adjustments: Suggest specific changes to hotspots, binder lengths, and generation parameters.
  • Plan Next Round: Define concrete steps, configurations, and expected improvements for future design campaigns.
  • Use Case: After running a design round for a protein target, use this Skill to review which strategies yielded the best binders, identify which parameters led to successful designs, and get a clear plan for the next round, including specific configuration changes.

Quick Start

Analyze the results from the latest design round and propose a plan for the next round.

Frequently Asked Questions about propose-designs

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I plan the next round of protein design after analyzing binder results?

To plan the next protein design round, you analyze performance metrics from previous results to suggest modifications to hotspots, binder lengths, and generation parameters, outputting a concrete job configuration for future design campaigns.

How do I compare BoltzGen and RFdiffusion performance for binder design?

You can compare BoltzGen and RFdiffusion performance by evaluating design metrics across different strategies to identify which tool yielded the best binders, helping you decide which generation parameters to adjust for the next round.

What parameters should I adjust when optimizing protein design strategies?

When optimizing protein design strategies, you should adjust target hotspots, binder lengths, and generation parameters based on performance metrics from previous design rounds to achieve expected improvements in binder quality.

Can I use design round results to automatically generate job configurations for RFdiffusion?

Yes, you can use design round results to generate concrete job configurations for RFdiffusion by evaluating performance metrics and outputting a specific plan that includes configuration changes and expected improvements for the next design campaign.

When do I need strategy analysis for protein design campaigns?

You need strategy analysis for protein design campaigns when you have completed a design round and need to make data-driven decisions to optimize strategies, identify successful parameters, and plan the next iteration for improved design outcomes.

Does protein design optimization work without previous round metrics?

Protein design optimization relies on previous round metrics to make data-driven decisions. Without performance metrics from prior design results, the skill cannot evaluate strategies or propose specific adjustments to hotspots and binder lengths for future rounds.