query-interpro

Retrieve InterPro domain, family, and functional-site annotations for UniProt entries.

30|2|Updated Mar 13, 2026
One-click install
npx skills add https://github.com/IDEA-XL/MolClaw --skill query-interpro-idea-xl
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: query-interpro
Source: https://github.com/IDEA-XL/MolClaw/tree/main/.claude/skills/query-interpro
Command: npx skills add https://github.com/IDEA-XL/MolClaw --skill query-interpro-idea-xl

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

Quickly retrieve protein-domain annotations (domains, families, and functional sites) from InterPro to answer biology questions about protein structure and function, without manual API calls.

Core Features & Use Cases

  • Domain & family lookup: fetch domains, families, and motif information for a given protein.
  • Functional-site identification: retrieve active/binding site data and motifs for curated insights.
  • Use Case: A researcher asks which InterPro entries map to a UniProt ID and what domains are present, enabling pathway and domain-architecture analysis.

Quick Start

Ask me to retrieve InterPro entries for a UniProt ID to obtain domains, families, and functional sites.

Frequently Asked Questions about query-interpro

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I retrieve InterPro protein domains for a specific UniProt ID?

To retrieve InterPro protein domains, provide a UniProt ID to fetch associated domains, families, and functional sites via the InterPro REST API. This returns curated annotations for pathway and domain-architecture analysis without manual API calls.

What is the best way to find active sites and motifs for a protein family?

Finding active sites and motifs involves querying InterPro entries for a given protein. This identifies curated active and binding site data alongside motif information, enabling functional-site analysis for protein families.

Can I get domain architecture and protein family annotations on demand?

Yes, you can get domain architecture and protein family annotations on demand. The Skill fetches InterPro entries mapping to a UniProt ID, retrieving structural and functional data to answer biology questions about protein structure.

Does the InterPro lookup handle missing entries or API errors?

Yes, the InterPro lookup handles missing entries and API errors gracefully. If a queried UniProt ID lacks InterPro annotations or the REST API fails, it manages the response without crashing, ensuring reliable domain retrieval.

When do I need to fetch InterPro entries for domain analysis?

You need to fetch InterPro entries for domain analysis when investigating protein structure, function, or pathway architecture. It applies when users ask about domain architecture, protein families, motifs, or functional sites for a given protein entry.