tooluniverse-drug-mechanism-research

Resolve the drug name to a ChEMBL ID via OpenTargets, then query OpenTargets or ChEMBL mechanism endpoints for targets, action types, and literature references. Supplement with the DailyMed clinical pharmacology section for the FDA-approved mechanism narrative.

Use KEGG gene-to-pathway lookups, Reactome UniProt-to-pathway mapping, or WikiPathways gene search with the target's gene symbol. For multi-target drugs, run Reactome or STRING pathway enrichment on the combined gene list to find convergent pathways.

It queries OpenTargets and ChEMBL for mechanisms and bioactivity, KEGG, Reactome, and WikiPathways for pathways, STRING for protein networks, DailyMed for FDA labels, CPIC and PharmGKB for pharmacogenomics, and PubMed/EuropePMC for literature.

Yes. Run the target identification and pathway mapping steps for both drugs, then align results by checking whether they share targets with different actions, hit different nodes in the same pathway, or act on entirely different pathways.

The skill defines fallback strategies for each step, such as using PharmGKB when OpenTargets drug resolution fails, WikiPathways when KEGG is unavailable, or EuropePMC when PubMed search fails. MetaCyc is unsupported and replaced by KEGG or Reactome.

Use other skills for adverse event profiling, drug repurposing, target druggability assessment, network pharmacology, or CPIC-specific dosing guidelines, as those are covered by dedicated ToolUniverse skills rather than this mechanism-tracing workflow.