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tooluniverse-neuroscience

Researches neuroscience questions using PubMed, WormBase, UniProt, and Allen Brain Atlas databases.

1.7k|254|Updated Mar 3, 2025
Search Tags:#neuroscience#pubmed#uniprot#connectome#neurodegeneration#neuroanatomy#wormbase
One-click install
npx skills add https://github.com/mims-harvard/ToolUniverse --skill tooluniverse-neuroscience
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: tooluniverse-neuroscience
Source: https://github.com/mims-harvard/ToolUniverse/tree/main/plugins/tooluniverse/skills/tooluniverse-neuroscience
Command: npx skills add https://github.com/mims-harvard/ToolUniverse --skill tooluniverse-neuroscience

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

Neuroscience questions about brain anatomy, neural circuits, ion channels, and neurological disease genetics require verified facts from specialized databases rather than reasoning from memory, which is error-prone for precise anatomical and molecular details.

Core Features & Use Cases

  • Literature-Verified Neuroanatomy: Looks up brain region functions, connectivity, and clinical localization via PubMed and EuropePMC instead of guessing.
  • Connectome and Protein Lookups: Queries WormBase for C. elegans neural circuits, UniProt for neural proteins and ion channels, and ClinVar/GWAS for neurological disease variants.
  • Computational Neuroscience: Guides quantitative problem-solving for integrate-and-fire neurons, STDP plasticity, and network dynamics using Python.
  • Use Case: Ask which brain region a stroke lesion localizes to given a set of cranial nerve findings, and receive an answer verified against published literature with correct UMN/LMN reasoning.

Quick Start

Ask the agent to look up the projection targets of a specific C. elegans neuron or verify the function of a brain region using the neuroscience research skill.

Frequently Asked Questions about tooluniverse-neuroscience

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I look up C. elegans neuron connectivity data?▼

Use the WormBase_get_gene tool with the specific neuron name to retrieve its presynaptic and postsynaptic partners and projection targets. The skill instructs never to guess connections from general knowledge, since actual synapse counts often differ from circuit diagram inferences.

How to verify brain region function with published literature?▼

Search PubMed or EuropePMC with queries like '[region] function review' or '[region] lesion' to confirm anatomical facts. The skill enforces a lookup-first principle because brain region boundaries and connectivity are precise facts that are easy to confuse from memory.

What databases does this neuroscience skill use for disease genes?▼

It uses ClinVar for neurological disease variants, GWAS for trait associations, Orphanet for rare neurological diseases, and UniProt for proteins like SNCA, LRRK2, and SOD1. OpenTargets supports drug target searches in neurological diseases.

Can it solve quantitative computational neuroscience problems?▼

Yes, it covers integrate-and-fire neuron firing rates, STDP plasticity windows, mean-field network dynamics, and Nernst/Goldman equations. It requires Python for all multi-step calculations and enforces unit checks in mV, ms, and Hz.

What are common pitfalls this skill helps avoid?▼

It flags errors like confusing GABA_A (ionotropic) with GABA_B (metabotropic) receptors, misplacing the substantia nigra, wrong unit conversions in membrane calculations, and ignoring hemispheric lateralization of language and spatial attention.

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