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blast-search

Performs nucleotide and protein sequence similarity searches via NCBI BLAST+ locally or remotely.

1|Updated Mar 12, 2026
Search Tags:#bioinformatics#blast#sequence similarity#homology search#gene identification#protein identification
One-click install
npx skills add https://github.com/yf8578/clawomics --skill blast-search-yf8578
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: blast-search
Source: https://github.com/yf8578/clawomics/tree/main/skills/blast-search
Command: npx skills add https://github.com/yf8578/clawomics --skill blast-search-yf8578

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes scripts (resource) and references (resource) components.

What problem does it solve?

This Skill enables users to perform sequence similarity searches against biological databases, helping to identify genes, proteins, and understand evolutionary relationships.

Core Features & Use Cases

  • Sequence Similarity Search: Find homologous sequences for a given DNA, RNA, or protein query.
  • Sequence Identification: Identify unknown genes or proteins by comparing them to known sequences.
  • Homology Analysis: Assess sequence conservation across different species.
  • Use Case: A researcher has a novel DNA sequence and wants to find out if it matches any known genes in the human genome.

Quick Start

Use the blast-search skill to run a blastn search for the provided DNA sequence against the human genome database.

Frequently Asked Questions about blast-search

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I run a sequence similarity search for a novel DNA sequence against a biological database?▼

To run a sequence similarity search, you can use this Skill to perform a blastn query against nucleotide databases, matching your DNA sequence against known genomic data to identify homologous genes.

What is the best way to identify unknown genes or proteins using homology search?▼

Homology search identifies unknown genes or proteins by comparing your query sequence against known biological databases using NCBI BLAST+, helping you find matching sequences and assess evolutionary relationships.

Do I need to select a specific BLAST program for nucleotide versus protein queries?▼

Yes, you must select the appropriate BLAST program for your query and database types, choosing from blastn, blastp, blastx, or tblastn to ensure accurate sequence similarity search results.

Can I search against remote NCBI databases instead of local sequences?▼

Yes, this Skill supports remote searches against NCBI databases, allowing you to perform sequence similarity searches without needing to host local biological databases.

How does sequence similarity search help with homology analysis across species?▼

Sequence similarity search assesses sequence conservation by aligning your query against databases, revealing homologous sequences across different species to help map evolutionary relationships.

When should I use blastx instead of blastn for gene identification?▼

You use blastx instead of blastn when you have a nucleotide query and want to search against a protein database, translating your query to identify protein-coding gene homologs.

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