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gtex-database

Query GTEx API v2 for eQTL and sQTL associations across 54 tissues.

1|Updated Mar 11, 2026
Search Tags:#api#data-analysis#gene-expression#biostatistics#eqtl#gtex#tissue
One-click install
npx skills add https://github.com/SciMate-AI/scicli --skill gtex-database-scimate-ai
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: gtex-database
Source: https://github.com/SciMate-AI/scicli/tree/main/internal/skills/bundled/claude-scientific-skills/skills/gtex-database
Command: npx skills add https://github.com/SciMate-AI/scicli --skill gtex-database-scimate-ai

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes references (resource) components.

What problem does it solve?

GTEx provides rich data to connect genetic variation with tissue-specific gene expression and regulatory effects; this skill enables programmatic access to GTEx data for research workflows.

Core Features & Use Cases

  • GTEx API access: fetch median gene expression by tissue, eQTL and sQTL associations, and tissue-level metadata.
  • Multi-tissue analysis: compare expression and regulatory signals across the 54 tissues to interpret GWAS results.
  • Data-driven interpretation: support variant-to-gene mapping and tissue-specific hypotheses for complex traits.

Quick Start

Run a query for a gene to retrieve its tissue-specific expression and associated eQTLs across GTEx tissues.

Frequently Asked Questions about gtex-database

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I query GTEx tissue-specific gene expression data for a specific gene?▼

You can query GTEx data by submitting a gene ID to retrieve median tissue-specific gene expression profiles across 54 tissues using GTEx API v2 endpoints, which return structured results including pval, qval, and slope.

Can I use GTEx API to map genetic variants to tissue-specific eQTLs?▼

Yes, the GTEx API allows you to map genetic variation to tissue-specific gene expression by querying eQTL and sQTL associations using variant IDs, supporting variant-to-gene mapping for complex traits.

What is the best way to compare eQTL regulatory signals across multiple GTEx tissues?▼

Comparing eQTL regulatory signals across 54 tissues is achieved by querying GTEx API v2 with gene IDs or variant IDs, which returns multi-tissue association metrics like pval, qval, and slope for analysis.

Does GTEx API v2 support pagination for large-scale eQTL data downloads?▼

Yes, GTEx API v2 supports pagination to handle large-scale data downloads, ensuring structured results for eQTL and sQTL analyses are returned efficiently for biostatistics and data-analysis workflows.

What data formats are returned when querying GTEx tissue expression profiles?▼

Querying GTEx tissue expression profiles returns structured results containing pval, qval, slope, and tissue identifiers, providing quantitative metrics for biostatistics and gene-expression analysis.

When should I use GTEx eQTL data for interpreting GWAS results?▼

GTEx eQTL data should be used to interpret GWAS results when you need to map variants to genes, compare regulatory signals across 54 tissues, and generate tissue-specific hypotheses for complex traits.

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