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gtex-database

Query the GTEx REST API v2 for tissue-specific gene expression and eQTL data.

1|Updated Mar 12, 2026
Search Tags:#bioinformatics#genomics#gene expression#eqtl#gtex#tissue-specific
One-click install
npx skills add https://github.com/yf8578/clawomics --skill gtex-database-yf8578
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: gtex-database
Source: https://github.com/yf8578/clawomics/tree/main/skills/gtex-database
Command: npx skills add https://github.com/yf8578/clawomics --skill gtex-database-yf8578

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill requires requests, pandas, and includes references (resource) components.

What problem does it solve?

This Skill helps researchers understand how genes are expressed across different human tissues and how genetic variations influence this expression, crucial for interpreting disease-associated genetic loci.

Core Features & Use Cases

  • Tissue-Specific Gene Expression: Query median expression levels (TPM) for any gene across 54 human tissues.
  • eQTL and sQTL Lookup: Find genetic variants associated with gene expression (eQTLs) or splicing (sQTLs) in specific tissues.
  • GWAS Variant Interpretation: Link non-coding GWAS variants to potential target genes by identifying eQTLs.
  • Use Case: Investigate if a gene linked to a specific disease shows higher expression in a particular tissue, or if a GWAS variant associated with that disease affects the expression of a nearby gene in relevant tissues.

Quick Start

Find the median expression level for the gene APOE across all GTEx tissues.

Frequently Asked Questions about gtex-database

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I find tissue-specific gene expression data for a gene like APOE?▼

To find tissue-specific gene expression, query the GTEx portal to retrieve median expression levels (TPM) for your target gene across 54 human tissues. This Skill utilizes the GTEx REST API v2 to fetch comprehensive expression data for any specified gene.

What is an eQTL and how does it help interpret GWAS variants?▼

An eQTL is a genetic variant associated with gene expression. By using this Skill to look up eQTLs, you can link non-coding GWAS variants to potential target genes, interpreting how variations influence expression patterns in specific human tissues.

Can I use this to identify sQTLs for splicing analysis in specific tissues?▼

Yes, you can identify sQTLs for splicing analysis. This Skill queries the GTEx portal for variants associated with splicing (sQTLs) across 54 human tissues, enabling you to find genetic variants affecting splicing in your tissues of interest.

Do I need pandas or requests installed to query the GTEx database?▼

Yes, you need both requests and pandas installed. These dependencies are required to utilize the GTEx REST API v2 for data retrieval and to structure the returned tissue-specific gene expression and eQTL data for analysis.

How do I check if a disease-associated genetic locus affects gene regulation?▼

To check if a disease-associated locus affects regulation, query GTEx for eQTLs and sQTLs at that variant. This links your genetic variations to gene expression and splicing patterns across 54 human tissues, revealing regulatory mechanisms.

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