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LeonChaoX
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interpro-database

Retrieve InterPro protein family, domain, and functional site annotations for UniProt accessions.

783|65|Updated Feb 27, 2026
Search Tags:#rest api#protein annotation#interpro#domain architecture#go term mapping#protein function prediction
One-click install
npx skills add https://github.com/LeonChaoX/qinyan-academic-skills --skill interpro-database-leonchaox
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: interpro-database
Source: https://github.com/LeonChaoX/qinyan-academic-skills/tree/main/skills/08-%E8%9B%8B%E7%99%BD%E8%B4%A8%E5%B7%A5%E7%A8%8B%E4%B8%8E%E7%BB%93%E6%9E%84%E7%94%9F%E7%89%A9%E5%AD%A6/interpro-database
Command: npx skills add https://github.com/LeonChaoX/qinyan-academic-skills --skill interpro-database-leonchaox

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes references (resource) components.

What problem does it solve?

This Skill helps you identify protein families, domains, and functional sites by querying the InterPro knowledge base and translating those annotations into actionable biological interpretation.

Core Features & Use Cases

  • InterPro REST API lookup: Retrieve InterPro entries (families, domains, superfamilies, repeats, and sites) mapped to a given UniProt protein.
  • Domain architecture analysis: Get the ordered domain/location layout across a protein sequence for downstream comparative analysis.
  • Functional inference via GO terms: Extract GO term annotations embedded in InterPro results to support functional characterization and hypothesis generation.

Use Case: You have a UniProt protein ID from a novel or poorly characterized gene; use InterPro to determine its domain composition (e.g., kinase + regulatory modules) and obtain associated GO terms for a first-pass functional annotation.

Quick Start

Use the interpro-database skill to query InterPro for UniProt accession P04637 and return its domain and GO term annotations.

Frequently Asked Questions about interpro-database

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I retrieve InterPro domain annotations for a UniProt protein accession?▼

To retrieve InterPro domain annotations, query the InterPro REST API with a UniProt accession. This returns JSON responses containing protein families, domains, superfamilies, repeats, and functional sites mapped to the protein.

What is domain architecture analysis and when do I need it for protein function prediction?▼

Domain architecture analysis determines the ordered domain and location layout across a protein sequence. You need it for downstream comparative analysis and evolutionary classification when characterizing novel genes.

Can I extract GO term mappings from InterPro entries for biological interpretation?▼

Yes, you can extract GO term mappings embedded in InterPro REST API results. These GO annotations support functional characterization and hypothesis generation for proteins with unknown functions.

Does the InterPro REST API require authentication keys for protein lookups?▼

No, the InterPro REST API requires authentication-free calls for protein lookups. You retrieve entry details and GO term extraction directly through standard JSON response handling without API keys.

What's the best way to handle batch annotation pipelines using InterPro data?▼

For batch annotation pipelines, iterate authenticated-free InterPro REST API calls across multiple UniProt accessions. Process the JSON responses to extract domain architectures and GO term mappings systematically.

Why does my InterPro REST API lookup return empty domain architecture results?▼

Empty domain architecture results occur when the queried UniProt accession lacks mapped InterPro entries. Verify the protein accession is valid and exists in the InterPro knowledge base before troubleshooting.

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