scientific-nci60-screening

Integrate NCI-60, CellMiner, and DepMap data to analyze cancer cell line drug responses.

3|1|Updated Feb 11, 2026
One-click install
npx skills add https://github.com/nahisaho/satori --skill scientific-nci60-screening
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: scientific-nci60-screening
Source: https://github.com/nahisaho/satori/tree/main/src/.github/skills/scientific-nci60-screening
Command: npx skills add https://github.com/nahisaho/satori --skill scientific-nci60-screening

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

Provides an integrated pipeline to analyze cancer cell line drug responses using NCI-60, CellMiner, and DepMap data, enabling robust cross-dataset insights.

Core Features & Use Cases

  • Integrates high-throughput screening data (GI50/LC50) and dependency scores to identify drug sensitivity patterns across cell lines.
  • Enables biomarker correlations between molecular features and drug responses, and cross-panel comparisons (NCI-60 vs DepMap).
  • Use Case: compare GI50 trends across cell lines and link them to molecular markers to prioritize compounds for further study.

Quick Start

Invoke the nci60_screening_pipeline with a drug name or NSC ID to produce integrated NCI-60/DepMap results.

Frequently Asked Questions about scientific-nci60-screening

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I analyze NCI-60 drug sensitivity data alongside DepMap dependency scores?

To analyze NCI-60 drug sensitivity with DepMap scores, this Skill integrates CellMiner GI50/LC50 data with dependency scores to identify drug response patterns across cancer cell lines. It cross-references datasets to pinpoint compound sensitivity trends for molecular marker prioritization.

What is the best way to correlate molecular biomarkers with GI50 drug response data?

Correlating biomarkers with GI50 drug response data requires integrating CellMiner molecular features with NCI-60 screening results. This Skill computes correlations between molecular markers and drug sensitivity values to prioritize compounds for further study.

Can I compare NCI-60 panel screening results directly with DepMap cell line data?

Yes, you can compare NCI-60 panel screening results directly with DepMap data. The Skill performs cross-panel comparisons between NCI-60 GI50/LC50 metrics and DepMap dependency scores to highlight overlapping or divergent cancer cell line responses.

Do I need internet access to fetch CellMiner and NCI-60 screening data for analysis?

Yes, internet access is required to fetch CellMiner and NCI-60 screening data for analysis. The Skill connects to public data sources to retrieve GI50, LC50, and DepMap dependency scores for Python-based analytics.

How do I retrieve integrated drug screening results using an NSC ID?

To retrieve integrated drug screening results using an NSC ID, invoke the pipeline with that specific drug identifier. The Skill fetches corresponding NCI-60 and DepMap data to produce a unified drug sensitivity and dependency report.